Nation-states tend to be large abstract concepts, none more so than the United States, which was born of a set of concepts.  But the foundations of every nation, its constituent elements, are vital places and regions.  Advanced geographers, in fact, have declared the region the cellular unit of the global economy.  The region is where life really happens, where economies take shape in the form of specialized economic clusters, where basic decisions are taken concerning transportation systems, land use, energy supplies, knowledge acquisition and cultural development.

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