{"id":357162,"date":"2021-10-21T14:11:33","date_gmt":"2021-10-21T14:11:33","guid":{"rendered":"https:\/\/theintercept.com\/?p=374103"},"modified":"2021-10-21T14:11:33","modified_gmt":"2021-10-21T14:11:33","slug":"ecohealth-alliance-conducted-risky-experiments-on-mers-virus-in-china","status":"publish","type":"post","link":"https:\/\/radiofree.asia\/2021\/10\/21\/ecohealth-alliance-conducted-risky-experiments-on-mers-virus-in-china\/","title":{"rendered":"EcoHealth Alliance Conducted Risky Experiments on MERS Virus in China"},"content":{"rendered":"

Documents released by<\/u> the National Institutes of Health yesterday raise new questions about government-funded research on viruses conducted in China. The annual grant reports from EcoHealth Alliance, which the NIH sent to The Intercept in response to a lawsuit<\/a>, provided additional evidence that the U.S. nonprofit \u2014 which studies\u00a0emerging infectious diseases \u2014 and its sub-awardee, the Wuhan Institute of Virology, were engaged in risky experiments and that the NIH may not have been fully aware of these activities.<\/p>\n

In September, The Intercept received two grant proposals<\/a> by EcoHealth Alliance that were submitted to the NIH. One of the proposals, \u201cUnderstanding the Risk of Bat Coronavirus Emergence<\/a>,\u201d detailed troubling and potentially dangerous research<\/a> conducted with bat coronaviruses in Wuhan, China. But the first release of the documents, which The Intercept received more than a year after it requested them, did not include the progress report for the grant\u2019s fifth and final funding year.<\/p>\n

<\/div>\n

Yesterday, the NIH provided that missing report for the period ending May 2019, which was inexplicably dated August 2021. That summary of the group\u2019s work includes a description of an experiment the EcoHealth Alliance conducted involving infectious clones of MERS-CoV, the virus that caused a deadly outbreak of Middle East respiratory syndrome in 2012. MERS has a case-fatality rate as high as 35 percent<\/a>, much higher than Covid-19\u2019s. The scientists swapped out the virus\u2019s receptor-binding domain, or RBD, a part of the spike protein that enables it to enter a host\u2019s cells, according to the report. \u201cWe constructed the full-length infectious clone of MERS-CoV, and replaced the RBD of MERS-CoV with the RBDs of various strains of HKU4<\/a>-related coronaviruses previously identified in bats from different provinces in southern China,\u201d the scientists wrote.<\/p>\n

\u201cChanging the receptor binding site on MERS (from DPP4 to ACE2) is sort of crazy,\u201d wrote Jack Nunberg, a virologist and director of the Montana Biotechnology Center at the University of Montana, in an email to The Intercept after reviewing the documents. Nunberg described the experiment as \u201cdefinitely gain of function,\u201d or experiments that may increase the transmissibility or virulence of pathogens, because it gave the virus \u201ca new receptor, a new host range, and unpredictable properties.\u201d A virus\u2019s host range is the range of species and cell types it is able to infect. The researchers\u2019 intent, which some scientists consider integral to defining gain-of-function, remains unclear.<\/p>\n\n

The Intercept previously asked EcoHealth Alliance about work on MERS-CoV referenced in sections of the grant that NIH released in September. At the time, EcoHealth spokesperson Robert Kessler insisted that the group had not conducted the work. \u201cThe MERS work proposed in the grant is suggested as an alternative and was not undertaken,\u201d Kessler wrote in an email in September. Kessler did not respond to a query The Intercept sent yesterday about the apparent falsity of his previous statement.<\/p>\n

The work with the MERS virus complicates EcoHealth Alliance\u2019s previous claims that the research covered in the grant had not involved work with \u201cpotential pandemic pathogens,\u201d or viruses, bacteria, and microorganisms that carry a likely risk of uncontrollable spread between humans. Kessler had previously told The Intercept that \u201cAll the other viruses studied under this grant are bat viruses, not human viruses.\u201d But MERS is known to infect and spread in humans, and was specifically designated under the NIH\u2019s former pause<\/a> on funding gain-of-function research of concern.<\/p>\n

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Other questions arise from the group\u2019s experiments with bat coronaviruses. As The Intercept previously reported, the EcoHealth Alliance grant proposals released in September contained descriptions of an experiment on mice that had been genetically engineered to contain an enzyme receptor found in human cells. These \u201chumanized mice\u201d were infected with bat coronaviruses containing parts of other viruses. At certain times during the experiment, the mutant viruses reproduced far more quickly in the mice than the original bat virus on which they were based and were also somewhat more pathogenic, leading several experts to conclude that they fit the NIH\u2019s definition of gain-of-function research<\/a>.<\/p>\n

The federal government temporarily paused such gain-of-function research involving potential pandemic pathogens in 2014, though it was resumed in 2017, when the Department of Health and Human Services introduced guidelines<\/a> known as P3CO, which were meant to safeguard against the risk of disease outbreak.<\/p>\n

In September, The Intercept asked the NIH whether anyone at the agency was aware of the humanized mouse experiments and whether, after they resulted in evidence of enhanced virus growth greater than 1 log over the parental backbone strain, the grantees were made to \u201cstop all experiments with these viruses and provide the NIAID Program Officer and Grants Management Specialist, and Wuhan Institute of Virology Institutional Biosafety Committee with the relevant data and information related to these unanticipated outcomes,\u201d as the grant had specifically required. We also asked why that research was not subject to either the temporary pause or the P3CO guidelines.<\/p>\n

In response, NIH spokesperson Elizabeth Deatrick wrote, \u201cThe PI [principle investigator] reported these results in the year 4 progress report and grant renewal application. The research described was reviewed, and was determined not subject to the 2014-2017 Gain-of-Function Research Funding Pause or to the P3CO Framework.\u201d<\/p>\n

Yet in a letter<\/a> sent to Rep.\u00a0James Comer, R-Ky., yesterday, NIH Principal Deputy Director Lawrence Tabak seemed to suggest that the agency had not<\/em> been aware of the problematic research. \u201cEcoHealth failed to report this finding right away, as was required by the terms of the grant,\u201d Tabak wrote to Comer, the ranking member of the House Committee on Oversight and Reform, which also received a copy of the annual progress report from the bat coronavirus grant yesterday.<\/p>\n

While critical of EcoHealth Alliance, Tabak also seemed to suggest that there was nothing alarming about the research, which he referred to as \u201climited experiments.\u201d After acknowledging that some of the humanized mice that were infected with the mutant viruses became sicker than those infected with the original viruses, he said the scientists had not been intent on that outcome. \u201cAs sometimes occurs in science, this was an unexpected result of the research, rather than something the researchers set out to do.\u201d<\/p>\n

Tabak also emphasized, as The Intercept has previously reported, that the viruses studied in the mouse experiments were so evolutionarily distant from SARS-CoV-2 that they could not have mutated into the virus that caused the Covid-19 pandemic. That view was echoed in a brief analysis<\/a> of the research that NIH posted to its website yesterday.<\/p>\n

<\/div><\/p>\n

Also among the documents NIH released to The Intercept yesterday was the original version of an annual report from the fourth year of the bat coronavirus grant. The version released to The Intercept in September indicated that it had been submitted in 2020, after the pandemic began and more than two years<\/a> after it was due. The two versions appear to be almost identical, though they include different reference publications. NIH has not yet released communications around the grant\u00a0that may explain why the document was updated.<\/p>\n

According to Tabak\u2019s letter, the NIH has demanded additional information from EcoHealth Alliance. \u201cEcoHealth is being notified that they have five days from today to submit to NIH any and all unpublished data from the experiments and work conducted under this award,\u201d he wrote. \u201cAdditional compliance efforts continue.\u201d<\/p>\n

“This is a pattern of dishonesty,” said Alina Chan,\u00a0a Boston-based molecular biologist and co-author of the upcoming book \u201cViral: The Search for the Origin of Covid-19.\u201d \u201cIt should be clear now that we cannot take the word of conflicted parties in the search for the origin of Covid-19,” said Chan. “It is urgently important that the public and investigators gain full access to all EcoHealth documents relating to research conducted in\u00a0Wuhan.\u201d<\/p>\n

The post EcoHealth Alliance Conducted Risky Experiments on MERS Virus in China<\/a> appeared first on The Intercept<\/a>.<\/p>\n\n

This post was originally published on The Intercept<\/a>. <\/p>","protected":false},"excerpt":{"rendered":"

Documents released by the NIH contradict previous assertions by the EcoHealth Alliance about its experiments on bat coronaviruses in Wuhan.<\/p>\n

The post EcoHealth Alliance Conducted Risky Experiments on MERS Virus in China<\/a> appeared first on The Intercept<\/a>.<\/p>\n","protected":false},"author":106,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,340],"tags":[],"_links":{"self":[{"href":"https:\/\/radiofree.asia\/wp-json\/wp\/v2\/posts\/357162"}],"collection":[{"href":"https:\/\/radiofree.asia\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/radiofree.asia\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/radiofree.asia\/wp-json\/wp\/v2\/users\/106"}],"replies":[{"embeddable":true,"href":"https:\/\/radiofree.asia\/wp-json\/wp\/v2\/comments?post=357162"}],"version-history":[{"count":7,"href":"https:\/\/radiofree.asia\/wp-json\/wp\/v2\/posts\/357162\/revisions"}],"predecessor-version":[{"id":359897,"href":"https:\/\/radiofree.asia\/wp-json\/wp\/v2\/posts\/357162\/revisions\/359897"}],"wp:attachment":[{"href":"https:\/\/radiofree.asia\/wp-json\/wp\/v2\/media?parent=357162"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/radiofree.asia\/wp-json\/wp\/v2\/categories?post=357162"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/radiofree.asia\/wp-json\/wp\/v2\/tags?post=357162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}